What is a Fundic Gland

Fundic glands are small, tube-shaped glands located in the lining of the stomach. They produce gastric juice, which contains hydrochloric acid and enzymes that help break down food. Fundic glands are lined with specialized cells that secrete different components of gastric juice, including parietal cells that secrete hydrochloric acid, chief cells that secrete pepsinogen (an inactive form of the enzyme pepsin), and mucous neck cells that secrete mucus. The mucus helps protect the lining of the stomach from the corrosive effects of gastric juice. Fundic glands are essential for digestion and play a role in regulating the pH of the stomach.

Fundic Glands: Location and Structure

Fundic glands, also known as oxyntic or gastric glands, are specialized glands found in the lining of the stomach. They play a crucial role in the digestive process by producing gastric acid and pepsin, essential for breaking down food and initiating digestion.


  • Fundic glands are located in the fundus and body of the stomach.
  • The fundus is the dome-shaped upper part of the stomach, while the body is the main central region.


Fundic glands are microscopic structures, each consisting of several types of cells:

  1. Mucous neck cells: Produce a protective layer of mucus that lines the stomach wall.
  2. Parietal cells: Secrete hydrochloric acid (HCl), the main component of gastric acid.
  3. Chief cells (peptic cells): Produce pepsin, an enzyme that breaks down proteins.
  4. Enteroendocrine cells: Release hormones that regulate stomach function.
Cell TypeFunction
Mucous neck cellsProtective mucus production
Parietal cellsHydrochloric acid secretion
Chief cells (peptic cells)Pepsin secretion
Enteroendocrine cellsHormone release

What is a Fundic Gland?

Fundic glands are small glands located in the stomach. They are responsible for producing gastric juice, which helps to digest food. Gastric juice is a clear, acidic liquid that contains digestive
enzymes. These glands are located in the fundus, which is the upper region of the stomach. Fundic glands are made up of several types of cells, including chief cells, parietal cells, and mucous neck cells.

Histology of Fundic Glands

The histology of fundic glands is complex, with several different types of cells. The main cell types are:

1. **Chief cells:** These cells produce pepsinogen, which is an inactive form of the digestive
enzyme pepsin.
2. **Parietal cells:** These cells produce hydrochloric acid, which is necessary for the activation of
peps kulanogen.
3. **Mucous neck cells:** These cells produce mucin, which is a type of glycoproteins that helps to
protect the stomach
lĂ­ning from the acidic environment.

The fundic glands are arranged in a honeycomb-like pattern. The chief cells are located in the
center of the glands, while the parietal cells are located on the
periphery. The mucous neck cells are located in between the chief and parietal cells.

The fundic glands are innervated by the vagus nerve. The vagus nerve
regulates the secretion of gastric juice. When the vagus nerve is
stimulated, the fundic glands produce more gastric juice.

Fundic Glands: Essential for Digestion

Fundic glands, located within the lining of the stomach, play a crucial role in digestion. These glands secrete a variety of substances that aid in breaking down food and preparing it for nutrient absorption in the small intestine.

Function of Fundic Glands in Digestion

  • Chief Cells: Secrete pepsinogen, which is converted into the active enzyme pepsin in the acidic environment of the stomach. Pepsin begins the digestion of proteins.
  • Parietal Cells: Secrete hydrochloric acid (HCl), creating the acidic environment necessary for pepsin activation. HCl also kills bacteria and denatures proteins.
  • Mucous Neck Cells: Secrete a protective layer of mucus that shields the stomach lining from the corrosive effects of HCl and pepsin.
  • Enteroendocrine Cells: Release hormones such as gastrin, which stimulates the production of gastric juice, and somatostatin, which inhibits gastric secretions.

Summary Table of Fundic Gland Secretions

Cell TypeSecretionFunction
Chief CellsPepsinogenConverts to pepsin for protein digestion
Parietal CellsHydrochloric acid (HCl)Acidic environment for pepsin activation, kills bacteria
Mucous Neck CellsMucusProtects stomach lining from HCl and pepsin
Enteroendocrine CellsGastrin, somatostatinRegulates gastric secretions

The coordinated secretion of these substances by fundic glands ensures efficient digestion of food, enabling the body to absorb and utilize the nutrients it contains.

Fundic Glands: Anatomy and Role in Acid Secretion

Fundic glands are specialized structures found in the lining of the stomach. They play a crucial role in producing hydrochloric acid (HCl), a key component of gastric juice, which helps break down food and protect against pathogens.

  • Structure: Fundic glands consist of several types of cells, each with a specific function:
Cell TypeFunction
Parietal CellsProduce hydrochloric acid
Chief CellsProduce pepsinogen, which is converted to the enzyme pepsin
Mucous Neck CellsSecrete mucus to protect the stomach lining
Enteroendocrine CellsRelease hormones and other signaling molecules

Role in Acid Secretion: The production of HCl by parietal cells is tightly regulated. When stimulated, the following steps occur:

  1. Hydrogen ions (H+) are pumped into the space between the cells (known as the gastric lumen).
  2. Bicarbonate ions (HCO3) are transported into the blood to maintain the body’s acid-base balance.
  3. H+ ions combine with chloride ions (Cl-) to form HCl.
  4. HCl is released into the gastric lumen, contributing to the acidity of the stomach.

Besides producing HCl, fundic glands also contribute to the overall physiology of the stomach. Mucous neck cells secrete mucus, which forms a protective barrier against the corrosive effects of gastric juice. Enteroendocrine cells release hormones, such as gastrin, that regulate stomach function.

Well, there you have it! That’s the lowdown on fundic glands. I hope this little excursion into the world of digestion left you feeling enlightened. Remember, your body is an incredible machine, and every part plays a vital role in keeping you healthy and functioning. So, let’s give our fundic glands a round of applause for their unwavering dedication to churning out that all-important gastric juice. Thanks for tuning in, and be sure to drop by again soon for more fascinating tidbits about the amazing human body!